Fatigue Relief Methyl B12 Plus
Cyanocobalmin is the most commonly supplemented form of vitamin B12, and this form of vitamin B12 does not naturally occur in plants or animal tissues. Another available form of B12 that offers significant advantages over cyanocobalmin is called methylcobalmin. This form of B!@ is called a co-enzyme form of B12, and is one step closer to being inserted into biological systems, because it eliminates one step that our body must do, to transform it for biological use. In addition there is a second form of B12 called “adenosylcobalamin”. Methylcobalamin and adenosylcobalamin are both considered active forms of B12, and they do appear to offer slightly different health advangages. Methylcobalamin and adenosylcobalamin are better absorbed and retained in higher amounts within your tissues. In general, methylcobalamin is used primarily in liver, brain and nervous system, while adenosylcobalamin is used mostly in the liver and for hemoglobin (blood cell) production.
One of the classic indications of B12 deficiency is a specialized form of anemia called macrocytic anemia. This usually shows up on a lab test as an increased mean size, your blood cells are a bit larger than normal should be. While iron is often the only thing given for anemia, this form of anemia usually has nothing to do with a lack of iron. B12 and folic acid are the nutrients you would need, and you need them to be plugged into enzymes. Because of this, the active forms of B12 are often more effective. Even with other forms of anemia, it is usually much more effective to combine iron supplementation with folic acid and these two active forms of vitamin B12.
These two forms of B12 also helps with deficiencies of the nervous system that may include numbness, tingling, loss of feeling sensation, burning sensations, muscle cramps, nerve pain and slowness of reflexes.
Because of methylcobalamin’s importance in nervous system health, it is also an important nutrient for vision. In fact, continued visual work (like work on a computer) often leads to a reduction in something called “visual accommodation”. Methylcobalamin can significantly improve visual accomodation while cyanocobalamin appears to be ineffective.
An elevated level of homocysteine is a metabolic indication of decreased levels of the co-enzyme forms of vitamin B12, especially methylcobalamin. Homocysteine has received a tremendous amount of emphasis in the scientific literature because of its associations with heart disease and a variety of other specific health conditions, have seen advertisements on television promoting folic acid as a vitamin needed to lower homocysteine. While this is true, and folic acid does lower homocysteine levels, the combination of methylcobalamin and folic acid appears to work much better.
Im people with liver disease, although high blood levels of vitamin B12 are common, it is not unusual to actually have a correspondingly low liver tissue concentration of vitamin B12 and its’ enzymes. In effect your locksmith can’t make keys anymore so the functions that depend on a complete and working B12 enzymes often suffer. Because of this, methylcobalamin and adenosylcobalamin should be the forms of B12 used under these circumstances. In fact, even under normal circumstances, the active forms of methylcobalamin and adenosylcobalamin help the liver function much more efficiently. Since our livers tend to be over worked due to the varieties of pollution and other environmental factors we are exposed to, these active forms of B12 can be valuable forms of additional nutritional support for the liver.
The most well studied use of methylcobalamin has to do with SLEEP. Although the exact mechanism of action is not yet clear, it is possible that methylcobalamin is needed for the synthesis of melatonin. Available information indicates that methylcobalamin can modulate melatonin secretion, enhance light-sensitivity, and normalize circadian rhythm (24 hour clock). Because of this, individuals supplementing this form of B12 often have improved quality of sleep, often requiring slightly less sleep, and will commonly report that they feel a bit more refreshed when waking in the morning. Methylcobalamin is particularly effective when the 24-hour clock is NOT running smoothly. This may be indicated by a need for excessive sleep, changing sleep-wake cycles, or a tendency to have altered sleep/wake patterns. Under all of these circumstances the combination of methylcobalamin (about 3000 mcg daily) and exposure to bright light in the morning can help re-establish the 24-hour clock
Because of methylcobalamins impact on the 24-hour clock and the cycles that feed off this, it is also and important vitamin to regulate your 24-hour release of the stress hormone cortisol. This seems to be particularly important for blood types A and AB. Methylcobalamin also seems to result in a better 24-hour maintenance of body temperature. Typically individuals supplementing this co-enzyme form of B12 have higher temperatures in the later hours of the daytime. This usually corresponds with improved alertness at the same time of the day.